"In the case of opioids, when the opioid molecule binds to mu receptors in the brain, it initiates the same biochemical sequence and dopamine release normally reserved for rewarding life-sustaining behaviors.3
Ironically, because the brain rewards opioid use in this same way, opioid use is positively reinforced just as though it were critical to survival. This "feeling" that opioid use is essential for survival is postulated as being responsible for many of the behavioral symptoms associated with opioid addiction."
(http://helpmegetoffdrugs.com)
"That is why addiction is a brain disease. As a person's reward circuitry becomes increasingly dulled and desensitized by drugs, nothing else can compete with them food, family, and friends lose their relative value, while the ability to curb the need to seek and use drugs evaporates. Ironically and cruelly, eventually even the drug loses its ability to reward, but the compromised brain leads addicted people to pursue it, anyway; the memory of the drug has become more powerful than the drug itself."
"That is why addiction is a brain disease. As a person's reward circuitry becomes increasingly dulled and desensitized by drugs, nothing else can compete with them food, family, and friends lose their relative value, while the ability to curb the need to seek and use drugs evaporates. Ironically and cruelly, eventually even the drug loses its ability to reward, but the compromised brain leads addicted people to pursue it, anyway; the memory of the drug has become more powerful than the drug itself."
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